Ticket to Ride: Ghost Train takes the gameplay of the Ticket to Ride series and scales it down for a younger audience.

In general, players collect parade float cards, claim routes on the map, and try to connect locations such as the Mad Scientist's Lab, the Gingerbread House, and the Lonely Barn that are shown on their tickets. In more detail, the game board shows a map of a city with certain locations being connected by colored paths. Each player starts with four colored parade float cards in hand and two tickets; each ticket shows two locations, and you're trying to connect those two locations with a contiguous path of your trains in order to complete the ticket.